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Advances in Blood Cells as Donor Cell to Generate iPSCs
Huang Xia, Li Yanxin*
Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China
Abstract: Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells resembling embryonic stem cells which can be directly generated from somatic cells by transcription factors or small molecule compounds. iPSCs are well known for their self-renewal ability and multilineage differentiation potential with less ethical issues as compared to ES cells， and have a great advantage in regenerative medicine， disease model and drug screening. In recent years， great breakthroughs of iPSCs technology have been made in the field of hematopoietic diseases. In this review， the progress of iPSCs study and its application in hematopoietic diseases are summarized.
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