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Exosomes Applied as Drug Carrier and Targeted Drug Delivery Strategies
Wang Ziyu, Zheng Ran, Ma Mingjun, Yuan Zhibo, Liang Yang*
College of Life Science, Northeast Forestry University, Harbin 150040, China
Abstract: Exosomes are 60-100 nm extracellular membrane vesicles from living cell by receptor-mediated endocytosis， macropinocytosis， or phagocytosis. Exosomes can be treated as safe drug delivery vehicles due to the fact that it involves in intercellular communication by attached to target cells via its surface molecules. As theranostic nanosystems， exosomes are small and highly immunological compatible which can deliver versatile cargos， such as the chemical molecules， proteins， generic-drugs. In this review， we summarize the recent progress in using exosomes for therapeutic， especially for target therapy， and discuss the advantages of exosomes as potential drug delivery vehicles and the potential challenges.
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