Advances in Effects of Mechanical Stress on Osteoclasts

Abstract: Osteoclast is a kind of bone tissue components. It is composed of multinuclear giant cells， which function as decomposing and absorbing bone tissue in vivo. It corresponds to osteoblasts in function and plays an important role in the dynamic balance of bone maintenance. Mechanical stress can promote the proliferation and differentiation of osteoblasts， reduce osteocyte apoptosis and improve the viability of bone cells and so on. Studies have shown that mechanical stress on osteoclasts can reduce osteoclast activity and inhibit bone resorption. The ability of osteoclast precursor cells to immortalize osteoclasts with immature osteoclasts under mechanical stress stimulation was different. The effects of mechanical stress on the viability of osteoclasts at different times and intensities were different also. In this paper， the effects of microgravity， compressive stress， tension and fluid shear stress on the differentiation of osteoclasts were reviewed.

CSTR: 32200.14.cjcb.2017.08.0016