Home > Browse Issues > Vol.39 No.8
Advances in Importin β1-Mediated Nuclear Transport of Viral Proteins in the Replication of Viruses
Hu Yan1, Xiong Jianmin1, Zhao Jiafu1, Ji Xinqin1,2*, Duan Zhiqiang1,2*
1College of Animal Science, Guizhou University, Guiyang 550025, China; 2Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, China
Abstract: Importin β1， an important member of the importin β family， is a kind of relatively conserved and widely distributed karyopherin in eukaryotic cells. Numerous studies have shown that importin β1 can directly recognize and bind the viral proteins carrying different types of nuclear localization signals and mediate the nuclear import of these proteins， which is essential for the replication and pathogenicity of many viruses. In this review， we have summarized the structure features of importin β1， the nuclear transport mechanism of viral proteins mediated by importin β1， the function of importin β1 in the replication of viruses and the drug targets related to importin β1 against virus infection， which will provide the literature basis to further study the molecular mechanism and functions of nuclear localization of viral proteins as well as antiviral treatment.
CN
EN