Home > Browse Issues > Vol.39 No.7
Methods for Differentiation of Umbilical Cord Mesenchymal Stem Cells into Insulin Producing Cells
Wang Jing1,2, Wu Yongjiang2, Wang Qi1, Qi Renli1,3, Huang Jinxiu1,3*
1Chongqing Academy of Animal Science, Chongqing 402460, China; 2Southwest University of Rongchang Campus, Chongqing 402460, China; 3The Key Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing 402460, China
Abstract: Dysfunction of pancreatic β cell can cause type 1 diabetes and part of type 2 diabetes. Transplantation of functional pancreatic β cell is an ideal therapy for diabetics. However， the serious shortage of donors restricted the clinical application of this therapy. At present， insulin producing cells (IPCs) have been used in the transplantation treatment for years instead pancreatic β cell. Umbilical cord mesenchymal stem cells (UCMSCs) are a pluripotent stem cells which can be induced into IPCs. Here， we reviewed the major induction methods of differentiate UCMSCs into IPCs， including multi-step induction method， genetic engineering method and co-culture method， and then tried to provide more information for futher improvement by comparing these methods.
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