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The Expression and Regulation Mechanism of ZNF143
Ye Bingyu, Xu Cunshuan*
State Key Laboratory Cultivation Base for Cell Differentiation Regulation, College of Life Science, Henan Normal University, Xinxiang 453007, China
Abstract: zinc finger protein 143 (ZNF143) containing seven zinc finger， belonged to C2H2-type transcription factor. ZNF143 is a ubiquitously expressed transcription factor conserved in most vertebrates. Usually， the expression of ZNF143 higher in tumor and during embryo development stage than that in normal tissues. ZNF143， which is by means of activation coding and non-coding genes， is widely participated in cell vital activities， such as cell cycle， cell proliferation， division and so on. And more importantly， ZNF143 is involved in long range chromatin interactions by cooperation with other regulatory proteins， and contribute to the formation of chromatin structure. This result indicates that ZNF143 plays a key role in cell identity and destiny determination. In addition， ZNF143 dysregulated expression are often accompanied with the occurrence of tumors， so it can be served as a drug-targeting molecule. Fortunately， it has already made some good progress on this front.
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