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Characteristics of Receptor-Type Protein Tyrosine Phosphatase Alpha and Its Function in Tumorigenesis
Zhang Jiaxu, Zhou Zijie, Yang Jiani, Bai Wenxin, Wang Jing, Huang Jian*
Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract: Receptor-type protein tyrosine phosphatase α (RPTPα)， a member of receptor-type protein tyrosine phosphatase (PTP) family， is widespread in cells， functioning as an important regulator in a variety of cellular processes， such as cell growth， differentiation， mitotic cycle， oncogenic transformation and so on. In this review， the fundamental properties of RPTPα， receptor dimerization and relative signal transduction pathway such as RPTPα- c-Src and integrin signaling are discussed to illuminate the molecular functions of RPTPα. Furthermore， current research progress of RPTPα and its relative signaling pathway in the oncogenesis of rectal cancer， breast cancer， gastric cancer is summarized specially. Based on that， this review proposes the direction for the subsequent study.
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