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The Biological Functions of NuMA Protein
Wu Jin, Wu Jianwei, Yu Zhichao, Zhang Qiong, Gong Ruizhi, Zhang Hongmei*
Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Abstract: Nuclear mitotic apparatus (NuMA) is a nuclear mitotic apparatus protein with high molecular weight. It has been more than 30 years since it was discovered at the first time in 1980. It has been found that NuMA plays important roles in mitotic spindle organization and maintenance， as well as post-mitotic nuclear reorganization. Moreover， overexpression of NuMA was closely related to the occurrence and development of multiple malignant tumors and the degradation of NuMA could lead to abnormal cell division and the decomposition of nuclear scaffold. In current paper， the expression and localization， alternatively splicing isoforms and interaction proteins of NuMA， as well as the progress in functions of NuMA in mitosis， asymmetric division and early development of nuclear transfer embryos were systematically reviewed.
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