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Advance on the Molecular Mechanism of Pink1/Parkin-Mediated Mitophagy
Tang Youjing1, Niu Yuna1,2, Wang Hui1,2*
1Research Center for Immunolgy, Xinxiang Medical University, Xinxiang 453003, China; 2Department of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China
Abstract: Mitophagy， the selective degradation of damaged mitochondria via autophagy dependent manner， is an important mitochondrial quality control system and regulated by a variety of pathways. In recent years， the regulation of mitophagy and its effects on physiology and pathology have been attracted increasing attention and obtained remarkable progress. The present evidence indicates that Pink1/Parkin pathway regulates mitochondrial dynamics and mediates the removal of damaged mitochondria via autophagy. Defects in PINK1/ PARK2 are the main cause of Parkinson’s disease. In addition， the dysfunction of Pink1/Parkin may have a role in the development of cancer. This review discribes the biochemical characteristics of Pink1/Parkin， highlights the molecular mechanism of mitopagy and its impact on the cellular processes.
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