Home > Browse Issues > Vol.39 No.7
Advances in Mouse Epiblast Stem Cell
Chen Yanglin, Liu Yueshi, Li Xihe*, Bao Siqin*
Research Center for Animal Genetic Resources of Mongolia Plateau College of Science, Inner Mongolia University, Hohhot 010021, China
Abstract: Mouse epiblast stem cell (mEpiSC) is derived from the epiblast tissue of mouse 5.5 days- 7.5 days embryos. Self-renewal and pluripotency of EpiSC is maintained by Activin/Nodal and FGF (fibroblast growth factor). Activin and FGF regulate pluripotency network. Culture system of EpiSC and separation methods still being explored. Compared with “naïve” state of mouse embryonic stem cell (mESC)， mEpiSC is thought to be in a state of “primed”. When mEpiSC is injected into blastocysts， the efficiency of chimeras is low. But it was easier to fuse with the implantation embryo when compared with mESC. Therefore， the EpiSC derived from the post-implantation embryo had essential difference compared with the mESC derived from the pre-implantation embryo， such as maintenance of pluripotent， developmental potential and induction method. In this review， EpiSC and ESC of mouse were compared， and a brief summary of recent advances in the knowledge of EpiSC had been given.
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