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Current Progress of Gene Editing Technique in Modern Porcine Breeding and Animal Model Establishment
Zhang Xia1,3, Liu Xiaoyan2,4, Miao Yiliang1,2,3*
1Institute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine,Huazhong Agricultural University, Wuhan 430070, China;
2Key Lab of Agricultural Animal Genetics,Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China;
3The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China;
4Reproductive Medicine Centre, Affiliated Hospital of Qingdao University, Yuhuangding Hospital of Yantai, Yantai 264000, China
2Key Lab of Agricultural Animal Genetics,Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China;
3The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China;
4Reproductive Medicine Centre, Affiliated Hospital of Qingdao University, Yuhuangding Hospital of Yantai, Yantai 264000, China
Abstract: Gene editing technology is a technology that can edit the target gene sequence and delete， insert and modify genome specific DNA fragment by artificial nucleic acid enzymes. Porcines are high quality livestock for meat production， however， people’s demand for fat and weight is changed to obtain a better quality of meat with the improvement of people’s living standards， which requires breeding and improving the main economic traits of porcines in lean meat percentage and meat quality to optimize the protein and fat content of pork. Besides， porcines are similar as to human in anatomy and physiology and they can be used in human disease models establishment，drug screening and the study of pathogenic mechanism. Gene editing technology can greatly reduce the time in modern porcine breeding and animal models of disease establishment， which makes porcines have greater potential in agricultural development and bio-medical research. This paper reviews traditional trans-genetic engineering and gene editing technologies in porcine breeding and animal models establishment and compares the advantages and disadvantages of each method. It provides a theoretical basis for porcine breeding and animal model establishment.
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