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Progress on Macrophages Receptors of Fungus Polysaccharide
Miao Yue1, Ren Guihong1, Jin Zhouyu1, Zhao Fei1, Song Hui1,2*
1School of Life Sciences, Jilin Agricultural University, Changchun 130118, China;
2Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China
2Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China
Abstract: The large edible fungus polysaccharide is closely related to the immune response， cell metabolism，cell carcinogenesis， and so on. It can not only affect the immune organs， but also activate the immune cells， such as macrophages， lymphocytes， dendritic cells and so on. There is a specific receptor on the surface of macrophages， which can bind to fungus polysaccharides， activate macrophages， and produce immune responses. It has been found that the fungus polysaccharide receptors including Toll-like receptors (TLRs)， dendritic cell-associated C-type lectin-1 (Dectin-1)， mannose receptor， complement receptor 3 and so on. The activation of intracellular signal transduction pathways by the recognition of external fungus polysaccharide ligands at the initial stage of the immune response， the eventual enhancement of phagocytosis， the promotion of NO production and cytokine secretion and a series of immune responses. However， the study of the mechanism of the effect of fungal polysaccharides on macrophage surface receptors needs to be further studied. These studies will help us to better understand the fine regulation of immune response mechanisms and find a new type of natural immune modulators.
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