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The Cytobiological Anti-cancer Mechanisms of Gambogic Acid
Wan-Yin Zhai, Shuang-Wen Zhou1, Chun-Pin Jia, Yuan-Sen Xu*
Lab of Nanotechnology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences,Shanghai 200050, China; 1School of Life Science, Fudan University, Shanghai 200062, China
Abstract: Gambogic acid is the major active component isolated from the gamboge resin of Garcinia hanburyi tree. In recent years， its prominent anti-tumor activity and low side effect has aroused widespread interest among scholars. Its anti-tumor mechanisms have been elucidated in (1) inhibition on tumor cell proliferation and induction of apoptosis， (2) activation T lymphocytes which stimulate apoptosis of tumor cells， and (3) inhibition on tumor angiogenesis. Although the molecular mechanism of its anticancer activity remains insufficient understood， its achievements have paved its way to the research in future and clinical application.
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