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Protein O-GlcNAc Modification and Its Cytobiology Function
Xin-Ying Yang, Jing Li, Mei-Yu Geng*
Laboratory of Molecular Pharmacology of Medicine and Pharmacy Institute, Ocean University of China, Qingdao 266003, China
Abstract: Glycosylation is one of the most important contents of protein posttranslational modification. Most of protein glycosylations take place at cells membrane and the glycan structure is complex. Another form of protein glycosylation， O-β-N-acetylglucosamine (O-GlcNAc)， existing extensively in nuclear and cytosolic proteins was observed recently， which will become the hotspot in glycobiology study increasingly for its special cell location and linkage style and the important role in cellular regulation. The unique carbohydrate modification O-GlcNAc and its application in cell biology was reviewed.
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