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The Function of Nrf2 in Metabolic Regulation and Its Role in Tumor Growth and Proliferation
Zhou Tianyu, Lü Xin, Chen Yutong, Fan Qiuju*, Cai Rong*
Department of Biochemistry & Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract: The Nrf2 [nuclear factor erythroid 2 (NFE2) related factor 2]， whose activity is regulated by Keap1 (Kelch-like-ECH associated protein 1) through proteasomal degradation， plays a cytoprotective role in the cell by facilitating downstream gene transcription for defending against oxidative stress and maintaining cellular redox homeostasis. Besides， the existence of Nrf2 in cells is of great significance in tumor metabolism and growth，which becomes one of the current research focuses in cell and cancer biology. In this paper， we reviewed the effects of Nrf2 on the generation and scavenging of ROS (reactive oxygen species) and cellular metabolism. In addition，we also focused on how Nrf2 affects tumor growth and proliferation through metabolic regulation， and introduced its relationship to tumor drug resistance in order to cast insight on further clinical research.
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