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The Mechanism of Mitochondria Quality Control in Mammals
Jia Zhenwei*
College of Animal Science and Technology, Inner Mongolia University for the Nationalities, Tongliao 028043, China
Abstract: Mitochondria are important intracellular organelles that not only provide energy for cellular activities via oxidative phosphorylation， but also closely associated with some important biological processes，including cell metabolism， stress signaling induction， calcium homeostasis， production of reactive oxygen species (ROS) and apoptosis. Mitochondrial quality control system plays a pivotal role in maintaining the normal cellular physiological function， however， mitochondrial dysfunction will lead to the occurrence of various diseases. Hence，in this review， we summarize current knowledge on the molecular mechanism of mitochondria quality control，which may provide reference for maintaining organisms health and reducing disease occurrence by modulating mitochondria quality.
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