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Structure and Functional Mechanism of the ADP-ribosylation Factor
Lei Wang, Hong-Yan Su*, Chang-Liu Wang, Chun-Hua Mu1
College of Life Sciences, Ludong University, Yantai 264025, China; 1Jinan Subcenter of National Maize Improvement Center, Jinan 250100, China
Abstract: ADP-ribosylation factors (ARFs) are members of the Ras superfamily of ~20 kDa guanine nucleotide binding proteins that were initially identified by their ability to stimulate cholera toxin-catalyzed ADP-ribosyltransferase activity of the α-subunit of G proteins. They have recently been implicated to function in vesicular trafficking and regulating the activation of phospholipase D， which play more important roles in cells to regulate membrane traffic and intracellular signal transduction system. Our topics range from the history of discovery to classification， gene structure and function， expression and physiological effects of this important protein.
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