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Renin-Angiotensin-Aldosterone System and Liver Fibrosis Research Progress
Hu Quandong1, Li Meijing2, Chen Qiongfeng1, Zhou Xiaoyan1*
1Institute of Basic Medical Science of Nanchang University, Nanchang 330006, China;
2Hepatic Surgery Two Area of Yantai Yuhuangding Hospital, Yantai 264000, China
2Hepatic Surgery Two Area of Yantai Yuhuangding Hospital, Yantai 264000, China
Abstract: Liver fibrosis is the transition of many chronic liver diseases to liver cirrhosis， which is characterized by the imbalance of extracellular matrix (ECM) synthesis and degradation， leading to a large amount of ECM deposition. During the development of liver fibrosis， it’s often accompanied by the activation of renin-angiontensin-aldosterone system (RAAS). The angiotensin-converting enzymeangiotensin II-angiotensin II type 1 repector (ACE-AngII-AT1R) and angiotensin-converting enzyme 2-angiotensin (1-7)-Mas [ACE2-Ang(1-7)-Mas] of RAAS are two most important regulating factors for the process of liver fibrosis.
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