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Tissue-Specific Stem Cells in the Aged Individual
Liu Qinggui, Chen Jiajia, Chen Fei, Wang Minjun*, Hu Yiping*
Department of Cell Biology, Second Military Medical University, Shanghai 200433, China
Abstract: Tissue-specific stem cells play a vital role in tissue homeostasis and regeneration. Aging tissues experiencing a progressive decline in regenerative function is considered as changes in number of tissue-specific stem cells， stem cell niches， proliferative and differentiation capacities. Moreover， the age-dependent diseases may be directly associated with these dysfunctional stem cells and their niches. Here， we explore the effects of aging on several reported tissue-specific stem cells in different tissues and molecular mechanisms underlying stem cells age.With this increased understanding， it is feasible to design and test interventions that delay or reversal tissue-specific stem cell aging and improve both health and lifespan.
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