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The ZO-1/ZONAB Signaling Pathways and Cell Proliferation and Differentiation
He Lixian, Tan Gang*
Department of Ophthalmology, The First Affiliated Hospital, University of South China, Hengyang 421001, China
Abstract: ZONAB (zonula occludens-1-associated nucleic-acid-binding protein)， which is recruited to tight junction by binding to the SH3 (Src homology 3) domain of ZO-1 (zonula occludens-1)， is a Y-box transcription factor. The interaction between ZO-1 and ZONAB is regulated by various types of cyclin-related genes， proteins， enzymes or transcription factors， which forms the ZO-1/ZONAB signaling circuitry. Recent evidence showed that ZO-1 and ZONAB interact to modulate cell proliferation， differentiation， genetic expression and morphogenesis， which were studied in the tissue of renal tubule， retinal pigment epithelium， choroid， alveolar epithelium， neuroglia and tumor. Though the specific regulating mechanisms remain unclear， the ZO-1/ZONAB signaling has shown great value of research in the field of cell regeneration， stem cells and oncology. In this article， we reviewed current studies of the ZO-1/ZONAB signaling pathways relating to cell proliferation and differentiation.
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