Home > Browse Issues > Vol.29 No.5
The Progress in Nuclear Reprogramming
Ling-Yan Wang, Xue-Ming Zhang, Zhan-Peng Yue, De-Xue Li, Zi-Yi Li*
Key Laboratory of Animal Embryo Engineering, Jilin Province; College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China
Abstract: Nuclear reprogramming is an important event in the mammalian development of normal and cloned embryos. And characteristic changes of nuclear reprogramming are mainly showed in epigenetic marking systems. During the formation and development of zygote， genome undergoes demethylation and acquires histone modifications. In cloned embryo， nuclear envelop breaks down and premature chromosome condensation occurs. Thereafter， the cloned embryo regains development potency to be a cloned animal. There are many factors involved in nuclear reprogramming. This review focuses on current progress of nuclear reprogramming in order to provide the clue for further investigations.
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