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Type 2 Innate Lymphoid Cells and Their Role in Allergic Asthma
Liu Chaobo, Sun Jun, Pan Xiuhe, Jiang Wenwen, Li Yan, Li Mingcai*
Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China
Abstract: Allergic asthma is a heterogeneous disease characterized by chronic airway inflammation and airway hyperreactivity， in which type 2 T helper cell (Th2) cytokines interleukin (IL)-4， IL-5， and IL-13 are closely associated with the symptoms. Type 2 innate lymphoid cells (ILC2s) arise， under the control of the transcription factors retinoic acid receptor related orphan receptor α (RORα) and GATA-binding factor 3 (GATA3)， from lymphoid progenitors in the bone marrow， to secrete Th2 cytokines including IL-5 and IL-13. ILC2s contribute to the initiation as well as to the maintenance of the adaptive type 2 immune response. Recent researches demonstrate that ILC2s play a key role in allergic asthma. The study of ILC2s has great significance to understand the pathogenesis of allergic asthma. This review will describe the recent progress on identification， development， distribution and function of ILC2s， and its relationship with allergic asthma.
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