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Progress of the Role-Aryl Hydrocarbon Receptor on Regulatory T cell
Ma Wei, Huang Wenjuan, Yu Jing, Yan Jun*, Liang Huaping*
State Key Laboratory of Trauma, Burns and Combined Injury, Department 1, Institute of Surgery Research,Daping Hospital, Third Military Medical University, Chongqing 400042, China
Abstract: T lymphocytes provide immune cellular function in adaptive immunity. As an important subset of T lymphocytes， regulatory T cell (Treg) can maintain immune tolerance and homeostasis effectively. Identifying the key factors that may affect the biological characteristics of Treg will help us interference with the development of Treg-related immune diseases and inflammation， and will have a potential value for clinical application in controlling inflammation and improving the prognosis of these diseases. The latest study found that the role of aryl hydrocarbon receptor (AhR) was closely concerned with these immune diseases and inflammatory response.Furthermore， activated AhR may influence the biological characteristics of Treg. This review summarized the role of AhR on Treg in the aspects of proliferation， differentiation， apoptosis and secretion， and discussed its related regulatory mechanisms.
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