Home > Browse Issues > Vol.39 No.1
Roles of Circular RNA in Head and Neck Cancers
Hao Wenjuan1,2, Shen Zhisen1,2*, Li Qun2, Guo Junming1*
1Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine,Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China;
2Department of Otorhinolaryngology, the Affiliated Lihuili Hospital, Ningbo University School of Medicine, Ningbo 315040, China
2Department of Otorhinolaryngology, the Affiliated Lihuili Hospital, Ningbo University School of Medicine, Ningbo 315040, China
Abstract: Circular RNA (circRNA) is closed continuous loops noncoding RNA. They are stably expressed in a variety of bio-logical cells， and have tissue specificity and other characteristics. Recently， the studies on circRNAs have shown that many circRNAs play roles as microRNA sponges， RNA-binding protein sponges， transcriptional regulators and so on. These roles give circRNAs a great potential in biological applications. Patients with head and neck cancers usually have serious troubles in respiration， swallowing and pronunciation. They suffer from pain of “hard to express” and have poor quality of life. As a result， to improve our understanding of this kind of cancers， this paper briefly reviewed the research progress of circRNA and their roles in head and neck cancers in recent years. The purpose is to bring some new view-points and bases for further study on circRNAs in head and neck cancers.
CN
EN