Advances in Ion Channels of Sperm with Patch Clamp Technical

Abstract: Spermatogenesis is a complex cellular event. Sperm ion channels play a central role in the regulation of spermatozoaion homeostasis and vital cellular processes such as motility， chemotaxis toward the egg and the acrosome reaction. Changes on the expression or function of some ion channels in spermatozoa directly affect male fertility of human and other animals. The most direct method for the study of ion channels is patch clamp technique， which appeared extremely difficult because of the size of spermatozoa and its motility. This review summarizes the function and electrophysiological character of sperm ion channels. We also discuss the pivotal usage of patch clamp technique in the study of sperm ion channel.

CSTR: 32200.14.cjcb.2017.01.0012