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The Progress on Haploid Embryonic Stem Cells Research
Chen Qiaoyu, Wang Junzheng, Li Rongfeng*
Key Laboratory of Xenotransplantation of Jiangsu Province, Nanjing Medical University, Nanjing 210029, China
Abstract: Mammalian embryonic stem cells are diploid and this character impedes their potential application on genetic screening. Recently， scientists have gained breakthrough in the haploid embryonic stem cells (haESCs) research field. The haESCs contain only one set of chromosome， express pluripotency markers and can differentiate into all three germ layers in vitro and in vivo， even more can support full-term development of mouse semi-cloned embryos via serving as oocyte or sperm. Therefore， the haESCs provide a powerful tool for researches on forward and reverse genetic， biological development and the assisted reproductive technology. Here we describe the haploid embryonic stem cell lines derivation and their characteristics， and summarize the progress on haESCs research and the application of haESCs. At the same time， we summarize the difficulties regarding the haploid embryonic stem cells research.
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