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RNA Interference Therapy
Jing-Jing Li, Zheng-Hai Ma, Fu-Chun Zhang*
State Key Laboratory Basis of Xinjiang Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumuqi 830046, China
Abstract: RNA interference (RNAi) was discovered in Caenorhabditis elegans firstly， then it was considered existing widely on eukaryotes (including fungi， plant and mammalian) and playing a role in gene regulation and cellular defense. At present， the breakthrough has achieved in RNAi molecular mechanism and gene function. In view of the sequence-specificity， effectivity and simplicity of the technology， RNAi has widespread application prospect in drug screening and therapy. However， it will be important to assess the safety of the RNAi-based therapies， and the further research on the systemic delivery of the siRNA should be done.
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