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Advances in the Relationship between Autophagy and Nrf2 Pathway
Liu Dan1, Li Xin2*
1Seven-Year-Program Second Clinical College, China Medical University, Shenyang 110013, China;
2School of Public Health, China Medical University, Shenyang 110013, China
2School of Public Health, China Medical University, Shenyang 110013, China
Abstract: Autophagy is a common phenomenon in human body， which plays a vital role in maintaining cellular homeostasis and metabolism. Nuclear factor erythroid-derived factor 2-related factor (Nrf2) functions as a crucial transcriptional factor in terms of regulating the cellular response against foreign bodies and oxidative damages. With further researches， a wide range of the crosstalk between Nrf2 pathway and autophagy was disclosed. Previous researches have found that inhibiting autophagy leads to accumulation of p62， thus combined with Kelch-like ECH-associated protein 1 (Keap1) and activating Nrf2 pathway. In addition， phosphatidyl inositol 3-kinase/protein kinase B (PI3K/Akt) pathway， reactive oxidative species (ROS) and other factors also participate in regulation between autophagy and Nrf2. In this review， we will discuss the progress that has been made in dissecting the intersection of these two pathways， providing new perspectives for the clinical therapy.
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