Targeting Cancer Therapy of Adeno-associated Virus Vector

Abstract: Targeting is the key point of success in cancer therapy. Cancer therapy based on virus vector must require specifically act on tumor cells meanwhile reducing the cytoxicity to the normal cells. Adeno-associated virus (AAV) vectors are widely used in treatment of human disease with the advantage of their low immune response， broad host range， and persistent and stable gene expression compared with other virus vectors. However， targeting cancer therapy mediated by AAV vectors still becomes the recent hot and difficult problem. In this review， we will focus on cancer therapy profile， recent progress in targeting strategies and the safety in the use of AAV vectors.

CSTR: 32200.14.cjcb.2007.05.0006