Advances in the Molecular Mechansim of Autophagy Formation

Abstract: Autophagy is an internal balancing mechanism to maintain homeostasis in eukaryotic cells. More autophagy-related proteins involved in the formation of autophagy have been discovered. For example， Atg1/ULK1 protease complexes mainly playing a critical role in the initial stage of the autophagy formation; Atg9•Atg2-Atg18 complexes mainly for the delivery of membrane structurein the process of autophagy formation; Atg12 and Atg5/LC3 binding system mainly involved in extending membrane and autophagy mature; Vps34-Atg6/Beclin1 PI(3)P enzyme complex playing an important role in the initiation and maturation of autophagy. Recent investigations have identified selectively in the recognition of autophagy substrates， such as mitophagy， lipophagy， xenophagy，etc. Therefore， autophagy is closely related to the occurrence and development of many diseases. Such as nervous system diseases， cancer， cardiovascular disease， infection， metabolic disease， idiopathic pulmonary， and pulmonary hypertension， and participates in the process of aging. At present， a number of autophagy regulators， which targeting autophagy are in clinical trials.

CSTR: 32200.14.cjcb.2016.12.0014