Prediction of Human miRNA Functions by Gene Cluster Discriminant Analysis

Abstract: With the development of new generation of sequencing technology， it seems impossible to find miRNA functions through biological experiment alone. So identifying the family for new miRNA and predicting its biological functions will provide a new method for experimental research. Based on the original family information， the unclassified or new miRNAs can be classified into a definited family with gene cluster discriminant analysis. The results show that there is a high degree of similarity among mature miRNAs in the same family. Considering that members in the same miRNA family participate in the same pathway or act on the same target genes， the same family miRNAs will have similar biological functions. Thus， the unclassified miRNA can be identified by gene cluster discrimination， which plays a vital role in experimentation and verification for new miRNA functions.

CSTR: 32200.14.cjcb.2016.12.0004