The Role of Beclin1-Vps34 in the Development of Autophagy

Abstract: Autophagy is a lysosome-dependent cellular catabolic process involved in the degradation of long-lived proteins and defective organelles. It is essential to maintain cellular homeostasis and to avoid cellular senescence. Current studies demonstrate that Beclin1-Vps34 complexes not only involved in autophagy regulation but also played a key role in tumor formation and development. This review focuses on the different Beclin1-Vps34 interacting partners， and how they associate in various ways to promote or inhibit autophagy. Here we sumarises the latest progress of Beclin1-Vps34 as the target of cancer treatment， and then raised new directions for future development.

CSTR: 32200.14.cjcb.2016.11.0015