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Roles of Alu Family in Human Genome
Wei Wang, Ya-Ping Wang*
Medical Department of Nanjing University, Nanjing 210093, China
Abstract: Alu family is the most important primate-specific short interspersed elements (SINEs). Over the last 65 million years， Alu repeats have propagated into a big family， which has about 1.2 million copies and comprises over 10% of the human geome. Alu repeats have many functions such as recombination， retrotransposition-mediated insertion and deletion， DNA methylation， A-to-I editing， regulation of transcription and translation， alternative splicing and so on. The mutation of Alu repeats is connected to the diseases and evolution.
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