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Regulation Effect of the Nutrition on the Proliferation and Differentiation of the Intestinal Stem Cells
Wen Min1,2, Jia Gang1*, Zhao Hua1, Chen Xiaoling1, Liu Guangmang1
1Animal Nutrition Institute, Sichuan Agricultural University, Yaan 625014, China;
2Tibet Vocational Technical College, Lasa 850000, China
2Tibet Vocational Technical College, Lasa 850000, China
Abstract: The function of the intestinal epithelium is depend on the regular proliferation and differentiation of the intestinal stem cells (ISCs) who reside at the base of the crypt. The surrounding cells and their affiliated growth factors consititute the niche for the ISCs， which regulate the function of the ISCs. The nutrients from the gut lumen can also act on the proliferation and differentaion of the ISCs， which may strongly influence the morphology and function of the intestinal epithelium. The Wnt/β-catenin and many other signal transduction pathways are involved in this regulation process. This paper briefly reviewed the recent progress in how the different nutrients regulate the prolifation and differentiation of the ISCs， providing new ideas about manipulation the proliferation and differentiation of the ISCs by means of nutrition.
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