Strategies to Enhance the Efficiency and Safety of Cell Reprogramming

Abstract: Cell reprogramming refers to the process of converting somatic cells to totipotent or pluripotent stem cell by dedifferentiation， or to another type of somatic cells or somatic stem cells by transdiffertiation under certain conditions. The cells derived from patient’s cells by reprogramming as seed cells for cell therapy， shares the specificity of patient， which could significantly reduce immune responses， provides multiple options in the source of seed cells with great value of clinical application. However， how to increase the efficiency of reprogramming and improve the safety of seed cells has been studied as a critical point in future clinic application. In recent years， researchers have been done a lot of work on how to optimize reprogramming strategy and have more comprehensive knowledge of the molecular mechanism involved in the process， such as epigenetic regulation and EMT. On the other hand， researchers adopt non-integrating episomal vectors and chemical induction to improve the safety of reprogramming. In this review， we have introduced the up-dated progress of this field.

CSTR: 32200.14.cjcb.2016.11.0011