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Toll-like Receptors and The Innate Immunity and Adaptive Immunity Mediated by Dendritic Cells
Yan Ye, Da-Jing Xia*
Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: Dendritic cells (DCs)， the most potent antigen-presenting cells (APC) which have been explored so far， play crucial roles in innate and adaptive immune response. Toll-like receptors (TLRs) are a group of conservative pattern-recognition receptors (PRR) in embryogenesis. They play an important role in the antigen recognition and presentation as well as in activation naive T cells by DCs. Moreover， they are also the check-points in regulating immunity when the host encounters antigens. This review will focus on the distribution of TLRs in different DCs subsets， the interactions with the innate immunity or adaptive immunity mediated by DCs， and the molecular basis of DCs functional plasticity.
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