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The Homeobox Gene Msx and Its Roles in Embryo Implantation
Zhou Guoqiang1, 2, Zhang Xumin2, Dai Shaojun1*, Wang Jingqiang2*
1Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040, China;
2State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China
2State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China
Abstract: The muscle segment homeobox (Msx) gene encoding product homeoprotein Msx belongs to the family of repressive transcription factor that has been shown to regulate multiple biological processes， such as the regulation of cell proliferation and apoptosis. Recent studies indicate that the Msx gene expression plays an important role in embryo implantation， and Msx gene has the specific expression with time and space in embryo implantation. At present， Msx gene controls the process of implantation through the negative regulation of Wnt family member 5a (Wnt5a). Msx gene in controlling embryonic diapause and activated again plays a conserved molecular switch role during embryo implantation. In this review， we introduced the mechanism of Msx gene in the molecular biological characteristics and its regulation in vivo specific target genes and discussed the main biological roles of Msx， in the embryo implantation and embryo diapause， and its possible mechanisms.
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