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Role of Reactive Oxygen Species in Tumor Development and Therapy
Duan Tanran1,2, Meng Chunchun2, Tang Zhaoxin1, Ding Chan2*
1South China Agricultural University, Guangzhou 510642, China;
2Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
2Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Abstract: Reactive oxygen species (ROS) is a phrase used to describe a variety of molecules and free radicals (chemical species with one unpaired electron) derived from molecular oxygen. ROS are tumorigenic by virtue of their ability to increase cell proliferation， survival， migration， and also by inducing DNA damage leading to genetic lesions that initiate tumorigenicity. The growing evidence suggests that ROS can induce cellular senescence and cell death. Therefore， it can be as an anti-tumorigenic agent candidate. In this review， we gave a brief overview of recent findings of the molecular mechanism of ROS generation， discussed the roles of ROS in tumor and focused on the roles of regulation ROS level in cancer development and treatment.
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