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Recent Advances in Circulating miR-155 As Tumor Biomarker
Yang Pan, Wang Ping, Zhou Jeff X*
Ningbo University School of Medicine, Ningbo 315211, China
Abstract: microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression through modulation of post-transcriptional activity. miRNAs have been shown to participate in the regulation of normal cellular function as well as disease development. Circulating miRNAs possess many advantages， including easy sampling and stability. miR-155 is highly expressed in various tumors， and the circulating miR-155 is aberrantly present during the tumor genesis and development. Studies have shown that circulating miR-155 could be used as a tumor marker for early diagnosis and real-time monitoring of tumors. This review discribed the recent progress of circulating miR-155 as tumor biomarker.
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