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The Roles of Long Non-Coding RNA in Hematopoiesis
Wang Fengjiao, Shi Lihong*, Cheng Tao*
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC,
The State Key Laboratory of Experimental Hematology, Tianjin 300020, China
Abstract: Genomic studies have uncovered that less than 2% of human genome encode proteins， while greater than 80% of the genome can be transcribed into RNA， namely non-coding RNA (ncRNA). Recently， the long non-coding RNA (lncRNA)， whose length is longer than 200 nucleotides， has been emerging as important regulator of cellular functions. The deep transcriptome sequencing data indicate that lncRNA is almost involved in all hematopoietic differentiation stages， such as maintaining the adult hematopoietic stem cell quiescence， regulating the enucleation of erythroblasts， modulating differentiation and immune response of lymphocytes， and so on. Further analyses reveal that lncRNA regulates the hematopoiesis mostly via transcription or post-transcription mechanism. Here， in this review，we will discuss recent advances and future perspectives of lncRNA in hematopoietic development.
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