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cAMP Signaling and Mitochondria Function in Animal Cell
Jia Zhenwei*
Institute of Yellow Cattle Genetics-Breeding and Reproduction, College of Animal Science and Technology,Inner Mongolia University for the Nationalities, Tongliao 028043, China
Abstract: Mitochondria are most important intracellular organelles which provide energy for cell life activities via oxidative phosphorylation. In addition， some important biological processes， like the growth， development and aging of cells are closely related to mitochondria. Accumulating evidences have shown that phosphorylation of mitochondrial proteins has emerged as an important player in the regulation of mitochondrial oxidative metabolism. Moreover， the ubiquitous second messenger cyclic adenosine monophosphate (cAMP) and its cellular effector protein kinase A (PKA) constitute one of the most widely studied signaling cascades， yet the roles of cAMP signaling and PKA phosphorylation of mitochondrial proteins in the regulation of mitochondrial metabolism remain controversial issues. Therefore， in this review， we summarized current knowledge on generation of cAMP and its signaling system in mitochondria， and the role of cAMP in regulating mitochondrial energy metabolism and other relevant aspects of mitochondrial signaling， which would give rise to a comprehensive understanding of the role of cAMP/PKA signal pathway in the control of mitochondrion function.
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