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Research Progress of microRNA Involved in Somatic Cells Reprogramming Induced to Differentiate into Neural Cells
Li Yuanyuan1,2, Wang Yuesi1,2*
1College of Pharmacy, Binzhou Medical University, Yantai 264003, China;
2Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, China
2Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, China
Abstract: Neurodegenerative disease is a common clinical disease. The treatment of these diseases only stays in the stage of drug therapy and surgery. Since the nerve cell is difficult to regeneration， it is very important to develop a new source of nerve cells for transplantation in the treatment of these diseases. The studies have demonstrated that mesenchymal stem cell (MSC)， embryonic stem cell (ESC) or induced pluripotent stem cell (iPSC) could differentiate into neural cells in vitro. Stem cell replacement treatment of neurodegenerative diseases will have excellent prospects. However， the limit of the low efficiency of nervous differentiation and the immune rejection has become an obstacle to the clinical application research. Studies have shown that microRNA (miRNA) has participation in nervous system development and differentiation and so on， and have the ability of reprogramming neural stem cells and treatment of neurodegenerative diseases. Therefore， this review makes a brief overview of miRNA involved in somatic cells reprogramming into neural cell’s mechanisms and the roles of miRNA reprogramming in the clinical application prospects.
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