Home > Browse Issues > Vol.38 No.9
Progress of Long Noncoding RNA in Colorectal Cancer
Lu Lizhen1, Li Jincheng1, Ye Meng2, Tao Yang1, Liao Qi1*
1Department of Prevention Medicine, School of Medicine, Ningbo University, Ningbo 315211, China;
2The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo 315100, China
2The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo 315100, China
Abstract: Long noncoding RNA (lncRNA) is a kind of functional molecule with length usually more than 200 nt. lncRNA can not encode proteins because of lacking a complete reading frame. However， more and more accumulated evidences verify that lncRNA plays a critical role in the development of many tumors. In colorectal cancer (CRC)， it has been already reported that a large number of lncRNA is significantly differentially expressed compared with normal cell and may act as oncogene or tumor suppressor in function participate in the metastasis of CRC， some of them even can be used as potential markers for the diagnosis or the therapy target of CRC. In this review，we mainly introduce the lncRNA act as oncogenes or tumor repressors in CRC and discuss their functions and regulation mechanisms.
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