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Progress in the Mechanisms of hUC-MSCs Differentiation into Hepatocyte-like Cells
Peng Qin1, Zhang Lei2*
1Kunming Medical University, Kunming 650500, China;
2Affiliated Calmette Hospital of Kunming Medical University/First Hospital of Kunming, Kunming 650011, China
2Affiliated Calmette Hospital of Kunming Medical University/First Hospital of Kunming, Kunming 650011, China
Abstract: Mesenchymal stem cells (MSCs) is a class of mesodermal multipotent stem cells， which are derived from the early developmental mesoderm. They widely distributed in connective tissues and organ stroma with characteristics of continuous self-renewal， proliferation and multipotential differentiation. With the progress of study in tissue engineering and regenerative medicine， MSCs have become a potential therapeutic tool for the treatment of various end-stage liver disease. Here， we reviewed the progress in biological characteristics of human umbilical cord mesenchymal stem cells (hUC-MSCs)， their differential ability into hepatocyte-like cells， as well as its possible mechanisms.
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