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The Effect of TETs on the Development of Primordial Germ Cell in Animals
Li Ming, Li Dongfeng, Du Wenxing, Yu Minli*
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Abstract: Primordial germ cell (PGC) is ancestor cell which can develop into the sperm and egg. The processes of PGC developing into germ cell include the removal of the original gene imprinting， the formation and maintenance of new imprinting， while DNA demethylation is the main mechanism responsible for these processes. The previous study indicates that TETs are involved in the control of DNA demethylation via different mechanisms. Ten-eleven translocations (TETs) play vital roles in primordial germ cell formation and embryonic development. In the present paper， we review the structure of TETs， the molecular mechanisms of DNA demethylation and their functions in the development of PGC in animals.
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