The Influence of Mechanical Loadon Bone Morphogenetic Protein Signaling Pathways in Bone

Abstract: Bone homeostasis is affected by several factors， particularly mechanical loading and growth factor signaling pathways. This review simply introduces the physiological and biochemical basic knowledge of bone morphogenetic protein signaling pathways (BMPs)， including the molecular structure of important proteins， signal transduction pathways and the two main independent pathways. Then， it introduces in detail the different forms of mechanical load (including gravity， pulling tension， stress， fluid shear) impact on BMPs in bone tissue. This review summarizes the mechanical stimulation has an effect on some important target genes， proteins， growth factors of BMPs. At the same time， through complementary literatures roughly， we induces mechanical stimulation has an impact on BMPs. We expect that extracellular physical signals turn into the biological electrical signals inside the cell changes by different pathways， through investigate the effect of the mechanical load on cells in vitro. We hope that this method could have an impact on the expression of related genes. It is helpful for us to study that exercise improve the growth period of peak bone mass， maintain or slow down the aging period， in order to prevent osteoporosis bone absorption.

CSTR: 32200.14.cjcb.2016.08.0017