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The Effects of Sports on the Signaling Pathways Associated with MSCs’Differentiation into Osteoblast
Li Guangzhou1, Wu Wei2*
1School of Sports and Health, Chongqing Three Gorges University, Chongqing 404100, China;
2Shanghai University of Sport, Shanghai 200438, China
2Shanghai University of Sport, Shanghai 200438, China
Abstract: Sports can affect the bone metabolism form the aspects of physical force， hormone and nutrition. This article was mainly stating that how sports affect the signal pathways of mesenchymal stem cells (MSCs) differentiation into osteoblast from transforming growth factor beta/bone morphogenetic protein (TGF-β/BMPs)， Wnt， mitogen-activated protein kinase (MAPK). It was found that sports intensity， time and types of muscles are important in the differentiation of MSCs to osteoblast. And more， rest after sports also play an important role in the differentiation of MSCs to osteoblast. This review provided theory reference for how sports affect bone metabolism.
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