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The Molecular Mechanisms of Insulinotropic Peptides on Pancreas Beta Cells
Zhao Chunlin, Huang Jingwen, Jin Lili, Wang Qiuyu*
Life Science School of Liaoning University, Shenyang 110031, China
Abstract: Insulinotropic active peptides have a series of functions on pancreas beta cells including promoting insulin secretion， increasing the quantity of islet beta cells， inhibiting the apoptosis of beta cells， etc. The investigation of their cell signaling pathways and molecular mechanisms would provide important messages for researching and developing novel therapeutic agents of type 2 diabetes mellitus， which would be high-efficient with low-side effect.Here we reviewed the progress of molecular mechanisms of several insulinotropic peptides on pancreas beta cells to provide the reference for the further related study.
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