Home > Browse Issues > Vol.38 No.8
Progress of the Induced Pluripotent Stem Cells in Domesticated Ungulates
Wu Xia, Wang Xiaoyun, Li Guangpeng*
The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology,College of Biosciences, Inner Mongolia University, Hohhot 010021, China
Abstract: Establishment of embryonic stem cell lines has been successful in mouse and human， but not in farm animals. Development of induced reprogramming technology has tremendous potential applications in regenerative medicine， animal breeding. It also offers an alternative approach for generation of pluripotent stem cells in domesticated ungulates. Recently， although porcine， bovine， ovine， caprine and equine iPSCs were derived from their somatic cells， compare to rodent and primate iPSCs， there were the gap in in vitro cultivation and cellular characteristics of ungulates iPSCs. As theoretical supports for iPSCs research in future， the aim of this review was to provide a systematic overview on iPSCs generation， substantial problems and solution in domesticated ungulates.
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