Home > Browse Issues > Vol.38 No.7
Effect of Some Cytokines on the Proliferation and Differentiation of Mammalian Neural Stem Cells
Xiao Jihan1#, Wang Shanshan1#, Zhou Lin2*
1The Second Clinical College, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China;
2Division of Histology and Embryology Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2Division of Histology and Embryology Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract: The proliferation and differentiation of neural stem cells (NSCs) are closely related to self-renewal and neuropathological lesion repair of the central nervous system (CNS). Cytokines-induced amplification and differentiation of NSCs contribute to the treatment of CNS injury. We here review the impacts of growth factor (GF)， interleukin (IL)， interferon (IFN) and other cytokines on NSCs proliferation and differentiation and the underlying mechanism. Among them， nerve growth factor (NGF)， bFGF， tumor necrosis factor-α (TNF-α) promote NSCs proliferation while IL-1β， IL-17， IFN-α inhibit NSCs proliferation. IL-1α， vascular endothelial growth factor (VEGF)， IFN-γ promote neural differentiatiation of NSCs while TNF-α， IL-1β promote glial differentiation. Some cytokines affect either NSCs proliferation or NSCs differentiation， while some have effects on them both. In addition， the effects of different subtypes of most cytokines are roughly the same， but a few may have different and even opposite effects.
CN
EN